|Application ||WB, IHC-P, IF, ICC|
|Dilution||ICC (1:100-1:200), IF (1:100-1:200), IHC-P (10 µg/ml), WB (1:500-1:3000) ,|
|Other Names||Complement component C9, Complement component C9a, Complement component C9b, C9|
|Target/Specificity||Human Complement C9.|
|Reconstitution & Storage||Aliquot and store at -20°C. Minimize freezing and thawing.|
|Precautions||Complement C9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.|
|Cellular Location||Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore|
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Provided below are standard protocols that you may find useful for product applications.
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
Stanley K.K.,et al.EMBO J. 4:375-382(1985).
Discipio R.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 81:7298-7302(1984).
Marazziti D.,et al.Biochemistry 27:6529-6534(1988).
Witzel-Schloemp K.,et al.Immunogenetics 48:144-147(1998).
DiScipio R.G.,et al.J. Biol. Chem. 260:14802-14809(1985).
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