|Application ||WB, IHC-P, IF, ICC|
|Dilution||IF (1:100-1:200), IHC-P (10 µg/ml), WB (1:500-1:3000)|
|Other Names||Alpha-actinin-2, Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein, ACTN2|
|Target/Specificity||Human alpha Actinin 2. Predicted cross-reactivity based on amino acid sequence homology: mouse (100%), rat (85%), bovine (84%), monkey (100%), zebrafish (86%).|
|Reconstitution & Storage||Aliquot and store at -20°C. Minimize freezing and thawing.|
|Precautions||ACTN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.|
|Cellular Location||Cytoplasm, myofibril, sarcomere, Z line Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle|
|Tissue Location||Expressed in both skeletal and cardiac muscle.|
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Provided below are standard protocols that you may find useful for product applications.
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Beggs A.H.,et al.J. Biol. Chem. 267:9281-9288(1992).
Tiso N.,et al.Biochem. Biophys. Res. Commun. 265:256-259(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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