|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (1:5000-1:20000),|
|Other Names||Insulin-degrading enzyme, 22.214.171.124, Abeta-degrading protease, Insulin protease, Insulinase, Insulysin, IDE|
|Target/Specificity||Human insulin degrading enzyme. Predicted cross-reactivity based on amino acid sequence homology: mouse (94%), rat (95%), bovine (98%), zebrafish (90%).|
|Reconstitution & Storage||Aliquot and store at -20°C. Minimize freezing and thawing.|
|Precautions||IDE Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.|
|Cellular Location||Cytoplasm. Cell membrane. Secreted. Note=Present at the cell surface of neuron cells The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform|
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Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
Affholter J.A.,et al.Science 242:1415-1418(1988).
Affholter J.A.,et al.Mol. Endocrinol. 4:1125-1135(1990).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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