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Dipeptidylpeptidase 8 / DPP8 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | Q6V1X1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 103kDa |
| Dilution | IF (1:100-1:200), IHC-P (10 µg/ml), WB (1:500-1:3000) |
| Gene ID | 54878 |
|---|---|
| Other Names | Dipeptidyl peptidase 8, DP8, 3.4.14.5, Dipeptidyl peptidase IV-related protein 1, DPRP-1, Dipeptidyl peptidase VIII, DPP VIII, Prolyl dipeptidase DPP8, DPP8, DPRP1 |
| Target/Specificity | Human DPRP1. |
| Reconstitution & Storage | Aliquot and store at -20°C. Minimize freezing and thawing. |
| Precautions | Dipeptidylpeptidase 8 / DPP8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DPP8 {ECO:0000303|PubMed:11012666, ECO:0000312|HGNC:HGNC:16490} |
|---|---|
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:32796818). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:34019797, PubMed:33731929, PubMed:33731932). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity). |
| Cellular Location | Cytoplasm |
| Tissue Location | Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function.
References
Abbott C.A.,et al.Eur. J. Biochem. 267:6140-6150(2000).
Qi S.Y.,et al.Biochem. J. 373:179-189(2003).
Sha J.H.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zhao B.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
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