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ELP3 Antibody

Rabbit Polyclonal Antibody

     
  • IF - ELP3 Antibody ALS13660
    Immunofluorescence of paraformaldehyde-fixed HeLa, using ELP3 antibody at 1:100 dilution.
  • WB - ELP3 Antibody ALS13660
    Sample (30 ug of whole cell lysate).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q9H9T3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 62kDa
Dilution IF (1:100-1:200), IHC-P (10 µg/ml), WB (1:500-1:3000)
Additional Information
Gene ID 55140
Other Names Elongator complex protein 3, hELP3, 2.3.1.48, ELP3
Target/Specificity Human ELP3. Predicted cross-reactivity based on amino acid sequence homology: mouse (96%), bovine (98%), zebrafish (92%).
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsELP3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELP3
Function Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (PubMed:19185337). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha- tubulin acetylation (By similarity).
Cellular Location Cytoplasm. Isoform 2: Cytoplasm. Nucleus.
Tissue Location Expressed in the cerebellum and spinal motor neurons.
Volume 50 µl
Citations (0)

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Background

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (PubMed:19185337). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha- tubulin acetylation (By similarity).

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Nusbaum C.,et al.Nature 439:331-335(2006).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Hawkes N.A.,et al.J. Biol. Chem. 277:3047-3052(2002).

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$ 395.00
Cat# ALS13660
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