|Application ||WB, IHC-P, E|
|Dilution||IHC-P (1:50), WB (1:1000),|
|Other Names||Antithrombin-III, ATIII, Serpin C1, SERPINC1, AT3|
|Reconstitution & Storage||Long term: -20°C; Short term: -20°C|
|Precautions||SERPINC1 / Antithrombin III Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Found in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Bock S.C.,et al.Nucleic Acids Res. 10:8113-8125(1982).
Chandra T.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:1845-1848(1983).
Tsuji H.,et al.(In) Yoshida T.O., Wilson J.M. (eds.);
Olds R.J.,et al.Biochemistry 32:4216-4224(1993).
Zhang C.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
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