|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:4000), IHC-P (3.75 µg/ml), WB (1:4000)|
|Other Names||Catechol O-methyltransferase, 188.8.131.52, COMT|
|Target/Specificity||Human COMT. This antibody is expected to recognise both reported isoforms. Variants (NP_000745.1; NP_001128633.1; NP_001128634.1) encode the same isoform.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||COMT Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.|
|Cellular Location||Isoform Soluble: Cytoplasm.|
|Tissue Location||Brain, liver, placenta, lymphocytes and erythrocytes|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Lundstroem K.,et al.DNA Cell Biol. 10:181-189(1991).
Bertocci B.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1416-1420(1991).
Tenhunen J.,et al.Eur. J. Biochem. 223:1049-1059(1994).
Li J.Y.,et al.Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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