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>   home   >   Products   >   Primary Antibodies   >   AHR Antibody (aa2-51)   

AHR Antibody (aa2-51)

Rabbit Polyclonal Antibody

     
  • IF - AHR Antibody (aa2-51) ALS13675
    Immunofluorescence of HeLa cells, using AhR (Ab-36) Antibody.
    detail
  • WB - AHR Antibody (aa2-51) ALS13675
    Western blot of extracts from 293 cells, using AhR (Ab-36) Antibody.
    detail
  • IHC - AHR Antibody (aa2-51) ALS13675
    Anti-Aryl Hydrocarbon Receptor antibody IHC of human skin.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P35869
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 96kDa
Dilution ELISA (1:1000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 196
Other Names Aryl hydrocarbon receptor, Ah receptor, AhR, Class E basic helix-loop-helix protein 76, bHLHe76, AHR, BHLHE76
Target/Specificity AhR (Ab-36) Antibody detects endogenous levels of total AhR protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsAHR Antibody (aa2-51) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AHR {ECO:0000303|PubMed:8393992, ECO:0000312|HGNC:HGNC:348}
Function Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:30373764, PubMed:23275542, PubMed:7961644, PubMed:32818467). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:30373764, PubMed:23275542, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic- binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644, PubMed:34521881). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32866000, PubMed:32818467). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
Cellular Location Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
Tissue Location Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle Expressed in retinal photoreceptors (PubMed:29726989)
Volume 50 µl
Citations (0)
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Background

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

References

Itoh S.,et al.Nucleic Acids Res. 21:3578-3578(1993).
Dolwick K.M.,et al.Mol. Pharmacol. 44:911-917(1993).
Ema M.,et al.J. Biochem. 116:845-851(1994).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS13675
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