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STEAP4 Antibody (aa201-250)

Rabbit Polyclonal Antibody

     
  • IF - STEAP4 Antibody (aa201-250) ALS13679
    Immunofluorescence of HeLa cells, using STEAP4 Antibody.
    detail
  • IHC - STEAP4 Antibody (aa201-250) ALS13679
    Anti-STEAP4 antibody IHC of human liver.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, E
Primary Accession Q687X5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 52kDa
Dilution ELISA (1:20000), IF (1:100-1:500), IHC-P (10 µg/ml)
Additional Information
Gene ID 79689
Other Names Metalloreductase STEAP4, 1.16.1.-, Six-transmembrane epithelial antigen of prostate 4, SixTransMembrane protein of prostate 2, Tumor necrosis factor, alpha-induced protein 9, STEAP4, STAMP2, TNFAIP9
Target/Specificity STEAP4 Antibody detects endogenous levels of total STEAP4 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsSTEAP4 Antibody (aa201-250) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STEAP4
Synonyms STAMP2 {ECO:0000303|PubMed:15897894}, TN
Function Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage- independent cell proliferation (PubMed:19787193).
Cellular Location Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein
Tissue Location Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.

References

Korkmaz C.G.,et al.Oncogene 24:4934-4945(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ohgami R.S.,et al.Nat. Genet. 37:1264-1269(2005).
Zhang C.M.,et al.Acta Pharmacol. Sin. 29:587-592(2008).

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$ 467.50
Cat# ALS13679
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