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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9)   

CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9)

Mouse Monoclonal Antibody

     
  • IF - CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9) ALS13688
    Cav1.3 (S48A-9), Human hippocampus.
  • IF - CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9) ALS13688
    Cav1.3 (S48A-9), Mouse back skin(2).
  • IF - CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9) ALS13688
    Cav1.3 (S48A-9), Mouse back skin.
  • IHC - CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9) ALS13688
    Anti-CACNA1D / Cav1.3 antibody IHC of rat brain.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, IP
Primary Accession Q01668
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S48A-9
Calculated MW 245kDa
Dilution ICC (0.1-1 µg/ml), IHC-P (10 µg/ml), IP (1-10 µg/ml), WB (1-10 µg/ml) ,
Additional Information
Gene ID 776
Other Names Voltage-dependent L-type calcium channel subunit alpha-1D, Calcium channel, L type, alpha-1 polypeptide, isoform 2, Voltage-gated calcium channel subunit alpha Cav1.3, CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Target/Specificity Detects ~250 kD protein. No cross-reactivity against Cav1.2.
Reconstitution & Storage Store at -20°C.
PrecautionsCACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CACNA1D
Synonyms CACH3, CACN4, CACNL1A2, CCHL1A2
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle
Research Areas
Citations (0)

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Background

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).

References

Williams M.E.,et al.Neuron 8:71-84(1992).
Seino S.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:584-588(1992).
Yamada Y.,et al.Genomics 27:312-319(1995).
Singh A.,et al.J. Biol. Chem. 283:20733-20744(2008).
Muzny D.M.,et al.Nature 440:1194-1198(2006).

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$ 395.00
Cat# ALS13688
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