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CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC, IP |
|---|---|
| Primary Accession | Q01668 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | S48A-9 |
| Calculated MW | 245kDa |
| Dilution | ICC (0.1-1 µg/ml), IHC-P (10 µg/ml), IP (1-10 µg/ml), WB (1-10 µg/ml) , |
| Gene ID | 776 |
|---|---|
| Other Names | Voltage-dependent L-type calcium channel subunit alpha-1D, Calcium channel, L type, alpha-1 polypeptide, isoform 2, Voltage-gated calcium channel subunit alpha Cav1.3, CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2 |
| Target/Specificity | Detects ~250 kD protein. No cross-reactivity against Cav1.2. |
| Reconstitution & Storage | Store at -20°C. |
| Precautions | CACNA1D / Cav1.3 Antibody (aa859-875, clone S48A-9) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CACNA1D |
|---|---|
| Synonyms | CACH3, CACN4, CACNL1A2, CCHL1A2 |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. |
| Cellular Location | Membrane; Multi- pass membrane protein |
| Tissue Location | Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
References
Williams M.E.,et al.Neuron 8:71-84(1992).
Seino S.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:584-588(1992).
Yamada Y.,et al.Genomics 27:312-319(1995).
Singh A.,et al.J. Biol. Chem. 283:20733-20744(2008).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
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