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FNBP1 / FBP17 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96RU3 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Hamster, Monkey, Pig, Horse, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 71kDa |
| Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), WB (1:32000) |
| Gene ID | 23048 |
|---|---|
| Other Names | Formin-binding protein 1, Formin-binding protein 17, hFBP17, FNBP1, FBP17, KIAA0554 |
| Target/Specificity | Human FNBP1. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | FNBP1 / FBP17 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FNBP1 |
|---|---|
| Synonyms | FBP17, KIAA0554 |
| Function | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes |
| Tissue Location | Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
References
Fuchs U.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:8756-8761(2001).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Richnau N.,et al.J. Biol. Chem. 276:35060-35070(2001).
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