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FNBP1 / FBP17 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - FNBP1 / FBP17 Antibody (Internal) ALS13695
    Antibody staining (0.25 ug/ml) of human testis lysate (RIPA buffer, 35 ug total protein per lane).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96RU3
Reactivity Human, Mouse, Rat, Zebrafish, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 71kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml), WB (1:32000)
Additional Information
Gene ID 23048
Other Names Formin-binding protein 1, Formin-binding protein 17, hFBP17, FNBP1, FBP17, KIAA0554
Target/Specificity Human FNBP1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsFNBP1 / FBP17 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FNBP1
Synonyms FBP17, KIAA0554
Function May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes
Tissue Location Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
Research Areas
Citations (0)

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Background

May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.

References

Fuchs U.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:8756-8761(2001).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Richnau N.,et al.J. Biol. Chem. 276:35060-35070(2001).

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$ 395.00
Cat# ALS13695
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