|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:128000), IHC-P (3.75 µg/ml), WB (1:128000)|
|Other Names||Arachidonate 5-lipoxygenase-activating protein, FLAP, MK-886-binding protein, ALOX5AP, FLAP|
|Target/Specificity||Human ALOX5AP / FLAP.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ALOX5AP / FLAP Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.|
|Cellular Location||Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Dixon R.A.F.,et al.Nature 343:282-284(1990).
Kennedy B.P.,et al.J. Biol. Chem. 266:8511-8516(1991).
Dunham A.,et al.Nature 428:522-528(2004).
Mancini J.A.,et al.FEBS Lett. 318:277-281(1993).
Woods J.W.,et al.J. Exp. Med. 178:1935-1946(1993).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.