|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:128000), IHC-P (3.75 µg/ml), WB (1:128000)|
|Other Names||Arachidonate 5-lipoxygenase-activating protein, FLAP, MK-886-binding protein, ALOX5AP, FLAP|
|Target/Specificity||Human ALOX5AP / FLAP.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ALOX5AP / FLAP Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.|
|Cellular Location||Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Dixon R.A.F.,et al.Nature 343:282-284(1990).
Kennedy B.P.,et al.J. Biol. Chem. 266:8511-8516(1991).
Dunham A.,et al.Nature 428:522-528(2004).
Mancini J.A.,et al.FEBS Lett. 318:277-281(1993).
Woods J.W.,et al.J. Exp. Med. 178:1935-1946(1993).
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