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ALOX5AP / FLAP Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - ALOX5AP / FLAP Antibody (Internal) ALS13698
    Antibody (0.1 ug/ml) staining of Human U937 cell lysate (35 ug protein in RIPA buffer).
    detail
  • IHC - ALOX5AP / FLAP Antibody (Internal) ALS13698
    Anti-ALOX5AP / FLAP antibody IHC of human lung.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P20292
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 18kDa
Dilution ELISA (1:128000), IHC-P (3.75 µg/ml), WB (1:128000)
Additional Information
Gene ID 241
Other Names Arachidonate 5-lipoxygenase-activating protein, FLAP, MK-886-binding protein, ALOX5AP, FLAP
Target/Specificity Human ALOX5AP / FLAP.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsALOX5AP / FLAP Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALOX5AP
Synonyms FLAP
Function Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Cellular Location Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Research Areas
Citations (0)
citation

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Background

Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.

References

Dixon R.A.F.,et al.Nature 343:282-284(1990).
Kennedy B.P.,et al.J. Biol. Chem. 266:8511-8516(1991).
Dunham A.,et al.Nature 428:522-528(2004).
Mancini J.A.,et al.FEBS Lett. 318:277-281(1993).
Woods J.W.,et al.J. Exp. Med. 178:1935-1946(1993).

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Discontinued
Cat# ALS13698
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