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EVC2 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q86UK5 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 148kDa |
| Dilution | ELISA (1:16000), IHC-P (3.75 µg/ml), |
| Gene ID | 132884 |
|---|---|
| Other Names | Limbin, Ellis-van Creveld syndrome protein 2, EVC2, EVC2, LBN |
| Target/Specificity | Human EVC2. This antibody is expected to recognise isoform 1 (NP_667338.3) and isoform 2 (NP_001159608.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | EVC2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EVC2 |
|---|---|
| Synonyms | LBN |
| Function | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8K1G2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8K1G2} Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8K1G2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8K1G2}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q8K1G2}. Nucleus {ECO:0000250|UniProtKB:Q8K1G2} Note=The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner {ECO:0000250|UniProtKB:Q8K1G2} |
| Tissue Location | Found in the heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development.
References
Takeda H.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:10549-10554(2002).
Ruiz-Perez V.L.,et al.Am. J. Hum. Genet. 72:728-732(2003).
Galdzicka M.,et al.Mol. Genet. Metab. 77:291-295(2002).
Ye X.,et al.Hum. Genet. 119:199-205(2006).
Sjoeblom T.,et al.Science 314:268-274(2006).
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