KIAA0517 / TRIM2 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9C040 |
Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Chicken, Horse, Xenopus, Bovine, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 82kDa |
Dilution | ELISA (1:16000), IHC-P (6.25 µg/ml), WB (0.5-2 µg/ml) |
Gene ID | 23321 |
---|---|
Other Names | Tripartite motif-containing protein 2, 6.3.2.-, E3 ubiquitin-protein ligase TRIM2, RING finger protein 86, TRIM2, KIAA0517, RNF86 |
Target/Specificity | Human TRIM2 / RNF86. This antibody is expected to recognise both reported isoforms (NP_056086.2; NP_001123539.1). Cross-reactivity with TRIM3 has been demonstrated. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | KIAA0517 / TRIM2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRIM2 |
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Synonyms | KIAA0517, RNF86 |
Function | UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). |
Cellular Location | Cytoplasm. |
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Background
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
References
Reymond A.,et al.EMBO J. 20:2140-2151(2001).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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