|Application ||WB, IHC-P, IF, E|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Tau-tubulin kinase 1, 220.127.116.11, Brain-derived tau kinase, TTBK1, BDTK, KIAA1855|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||TTBK1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.|
|Tissue Location||Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.|
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Provided below are standard protocols that you may find useful for product applications.
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
Sato S.,et al.J. Neurochem. 98:1573-1584(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Nagase T.,et al.DNA Res. 8:85-95(2001).
Greenman C.,et al.Nature 446:153-158(2007).
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