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GNPDA2 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC, E |
|---|---|
| Primary Accession | Q8TDQ7 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 31kDa |
| Dilution | ICC (4 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml) |
| Gene ID | 132789 |
|---|---|
| Other Names | Glucosamine-6-phosphate isomerase 2, 3.5.99.6, Glucosamine-6-phosphate deaminase 2, GNPDA 2, GlcN6P deaminase 2, Glucosamine-6-phosphate isomerase SB52, GNPDA2, GNP2 |
| Target/Specificity | Human GNPDA2 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | GNPDA2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNPDA2 {ECO:0000303|PubMed:26887390} |
|---|---|
| Synonyms | GNP2 |
| Function | Catalyzes the reversible conversion of alpha-D-glucosamine 6- phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Ubiquitous, with highest expression detected in testis, ovary, placenta, and heart. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Zhang J.,et al.J. Cell. Biochem. 88:932-940(2003).
Xu J.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
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