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PCDH12 / VE-Cadherin-2 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NPG4 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 129kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 51294 |
|---|---|
| Other Names | Protocadherin-12, Vascular cadherin-2, Vascular endothelial cadherin-2, VE-cad-2, VE-cadherin-2, PCDH12 |
| Target/Specificity | Human PCDH12 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | PCDH12 / VE-Cadherin-2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PCDH12 (HGNC:8657) |
|---|---|
| Function | Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell- cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). |
| Cellular Location | [Protocadherin-12]: Cell membrane; Single-pass type I membrane protein. Cell junction {ECO:0000250|UniProtKB:O55134} |
| Tissue Location | Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression (PubMed:11063261). Prominent expression in the spleen (PubMed:11063261). Present in villous and extravillous trophoblast (at protein level) (PubMed:21402705). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).
References
Wu Q.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000).
Ludwig D.,et al.Mamm. Genome 11:1030-1033(2000).
Seki N.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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