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OTUD4 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC, E |
|---|---|
| Primary Accession | Q01804 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 124kDa |
| Dilution | IHC-P (5 µg/ml), WB (0.25-0.5 µg/ml), |
| Gene ID | 54726 |
|---|---|
| Other Names | OTU domain-containing protein 4, 3.4.19.12, HIV-1-induced protein HIN-1, OTUD4, HIN1, KIAA1046 |
| Target/Specificity | Human OTUD4 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | OTUD4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OTUD4 (HGNC:24949) |
|---|---|
| Function | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase- substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). |
| Cellular Location | Cytoplasm. Nucleus. Note=Primarily cytoplasmic |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Raineri I.,et al.Nucleic Acids Res. 20:6261-6266(1992).
Bienvenut W.V.,et al.Submitted (JUL-2007) to UniProtKB.
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