KLHL15 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, ICC, E |
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Primary Accession | Q96M94 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 70kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 80311 |
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Other Names | Kelch-like protein 15, KLHL15, KIAA1677 |
Target/Specificity | Human KLHL15 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | KLHL15 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KLHL15 |
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Synonyms | KIAA1677 |
Function | Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:27561354, PubMed:14528312, PubMed:35219381). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation (PubMed:27561354, PubMed:35219381). Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354, PubMed:35219381). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nagase T.,et al.DNA Res. 7:347-355(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Furukawa M.,et al.Nat. Cell Biol. 5:1001-1007(2003).
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