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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   KLHL15 Antibody (C-Terminus)   

KLHL15 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - KLHL15 Antibody (C-Terminus) ALS13750
    Immunocytochemistry of KLHL15 in HeLa cells with KLHL15 antibody at 5 ug/ml.
    detail
  • IF - KLHL15 Antibody (C-Terminus) ALS13750
    Immunofluorescence of KLHL15 in HeLa cells with KLHL15 antibody at 20 ug/ml.
    detail
  • WB - KLHL15 Antibody (C-Terminus) ALS13750
    Western blot of KLHL15 in HeLa cell lysate with KLHL15 antibody at (A) 1 and (B) 2 ug/ml.
    detail
  • IHC - KLHL15 Antibody (C-Terminus) ALS13750
    Anti-KLHL15 antibody IHC of human prostate.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession Q96M94
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 70kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 80311
Other Names Kelch-like protein 15, KLHL15, KIAA1677
Target/Specificity Human KLHL15
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsKLHL15 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL15
Synonyms KIAA1677
Function Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:27561354, PubMed:14528312, PubMed:35219381). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation (PubMed:27561354, PubMed:35219381). Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354, PubMed:35219381).
Cellular Location Nucleus.
Research Areas
Citations (0)
citation

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Background

Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nagase T.,et al.DNA Res. 7:347-355(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Furukawa M.,et al.Nat. Cell Biol. 5:1001-1007(2003).

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$ 467.50
Cat# ALS13750
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