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CTMP / THEM4 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IF - CTMP / THEM4 Antibody (Internal) ALS13752
    Immunofluorescence of THEM4 in human liver tissue with THEM4 antibody at 20 ug/ml.
  • WB - CTMP / THEM4 Antibody (Internal) ALS13752
    Western blot of THEM4 in human liver tissue lysate with THEM4 antibody at (A) 1 and (B) 2 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q5T1C6
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 27kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 117145
Other Names Acyl-coenzyme A thioesterase THEM4, Acyl-CoA thioesterase THEM4, 3.1.2.2, Carboxyl-terminal modulator protein, Thioesterase superfamily member 4, THEM4, CTMP
Target/Specificity Human THEM4
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCTMP / THEM4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THEM4
Synonyms CTMP
Function Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.
Cellular Location Cell membrane. Cell projection, ruffle membrane Cytoplasm. Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein Mitochondrion intermembrane space. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli
Tissue Location Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.
Research Areas
Citations (0)

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Background

Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.

References

Maira S.-M.,et al.Science 294:374-380(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Knobbe C.B.,et al.J. Natl. Cancer Inst. 96:483-486(2004).

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$ 395.00
Cat# ALS13752
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