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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TNIP3 Antibody (C-Terminus)   

TNIP3 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - TNIP3 Antibody (C-Terminus) ALS13762
    Western blot of ABIN3 in human spleen tissue lysate with ABIN3 antibody at 1 ug/ml in (A) the...
  • IHC - TNIP3 Antibody (C-Terminus) ALS13762
    Anti-TNIP3 antibody IHC of human adrenal.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96KP6
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 79931
Other Names TNFAIP3-interacting protein 3, A20-binding inhibitor of NF-kappa-B activation 3, ABIN-3, Listeria-induced gene protein, TNIP3 (HGNC:19315), ABIN3, LIND
Target/Specificity Human TNIP3
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsTNIP3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNIP3 (HGNC:19315)
Synonyms ABIN3, LIND
Function Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
Tissue Location Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis, placenta, thyroid, uterus, prostate, skin and PBL.
Research Areas
Citations (0)

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Background

Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.

References

Staege H.,et al.Immunogenetics 53:105-113(2001).
Wullaert A.,et al.J. Biol. Chem. 282:81-90(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13762
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