|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Lysine-specific demethylase 8, 22.214.171.124, JmjC domain-containing protein 5, Jumonji domain-containing protein 5, KDM8, JMJD5|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||KDM8 / JMJD5 / FLJ13798 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.|
|Tissue Location||Weakly expressed in most cells. Highly expressed in breast cancer cells.|
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Provided below are standard protocols that you may find useful for product applications.
Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Li H.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Martin J.,et al.Nature 432:988-994(2004).
Hsia D.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 107:9671-9676(2010).
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