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KDM8 / JMJD5 / FLJ13798 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - KDM8 / JMJD5 / FLJ13798 Antibody (C-Terminus) ALS13772
    Immunofluorescence of JMJD5 in Rat Liver cells with JMJD5 antibody at 20 ug/ml.
  • IHC - KDM8 / JMJD5 / FLJ13798 Antibody (C-Terminus) ALS13772
    Anti-JMJD5 antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8N371
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 47kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 79831
Other Names Lysine-specific demethylase 8, 1.14.11.27, JmjC domain-containing protein 5, Jumonji domain-containing protein 5, KDM8, JMJD5
Target/Specificity Human JMJD5
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsKDM8 / JMJD5 / FLJ13798 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM8
Synonyms JMJD5
Function Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
Cellular Location Nucleus.
Tissue Location Weakly expressed in most cells. Highly expressed in breast cancer cells.
Research Areas
Citations (0)

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Background

Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Li H.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Martin J.,et al.Nature 432:988-994(2004).
Hsia D.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 107:9671-9676(2010).

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$ 395.00
Cat# ALS13772
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