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PLEKHM2 / SKIP Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - PLEKHM2 / SKIP Antibody (C-Terminus) ALS13787
    Immunofluorescence of PLEKHM2 in Human Brain cells with PLEKHM2 antibody at 20 ug/ml.
    detail
  • WB - PLEKHM2 / SKIP Antibody (C-Terminus) ALS13787
    Western blot of PLEKHM2 in rat brain tissue lysate with PLEKHM2 antibody at 0.5 ug/ml in (A) the...
    detail
  • IHC - PLEKHM2 / SKIP Antibody (C-Terminus) ALS13787
    Anti-PLEKHM2 antibody IHC of human skeletal muscle.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8IWE5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 113kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 23207
Other Names Pleckstrin homology domain-containing family M member 2, PH domain-containing family M member 2, Salmonella-induced filaments A and kinesin-interacting protein, SifA and kinesin-interacting protein, PLEKHM2, KIAA0842, SKIP
Target/Specificity Human PLEKHM2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsPLEKHM2 / SKIP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLEKHM2 (HGNC:29131)
Function Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:28325809, PubMed:22172677, PubMed:25898167, PubMed:24088571). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402).
Cellular Location Cytoplasm. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side
Research Areas
Citations (0)
citation

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Background

May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.

References

Nagase T.,et al.DNA Res. 5:355-364(1998).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Boucrot E.,et al.Science 308:1174-1178(2005).

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Discontinued
Cat# ALS13787
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