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KCNK18 / TRESK Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IF - KCNK18 / TRESK Antibody (Internal) ALS13802
    Immunofluorescence of TRESK in Rat Brain cells with TRESK antibody at 20 ug/ml.
  • WB - KCNK18 / TRESK Antibody (Internal) ALS13802
    Western blot of TRESK in rat brain tissue lysate with TRESK antibody at (A) 1 and (B) 2 ug/ml.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q7Z418
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 44kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 338567
Other Names Potassium channel subfamily K member 18, TWIK-related individual potassium channel, TWIK-related spinal cord potassium channel, KCNK18, TRESK, TRIK
Target/Specificity Human KCNK18
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsKCNK18 / TRESK Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNK18
Synonyms TRESK, TRIK
Function Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord.
Research Areas
Citations (0)

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Background

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).

References

Sano Y.,et al.J. Biol. Chem. 278:27406-27412(2003).
Deloukas P.,et al.Nature 429:375-381(2004).
Liu C.,et al.Anesth. Analg. 99:1715-1722(2004).
Dobler T.,et al.J. Physiol. (Lond.) 585:867-879(2007).
Egenberger B.,et al.Biochem. Biophys. Res. Commun. 391:1262-1267(2010).

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$ 395.00
Cat# ALS13802
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