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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PKDCC / SGK493 Antibody (Internal)   

PKDCC / SGK493 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IF - PKDCC / SGK493 Antibody (Internal) ALS13804
    Immunofluorescence of VLK in rat lung tissue with VLK antibody at 5 ug/ml.
  • WB - PKDCC / SGK493 Antibody (Internal) ALS13804
    Western blot of VLK in human lung tissue lysate with VLK antibody at 1 ug/ml.
  • IHC - PKDCC / SGK493 Antibody (Internal) ALS13804
    Anti-PKDCC antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q504Y2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 54kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 91461
Other Names Extracellular tyrosine-protein kinase PKDCC, 2.7.10.2, Protein kinase domain-containing protein, cytoplasmic {ECO:0000312|HGNC:HGNC:25123}, Protein kinase-like protein SgK493, Sugen kinase 493, Vertebrate lonesome kinase, PKDCC (HGNC:25123)
Target/Specificity Human PKDCC
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsPKDCC / SGK493 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PKDCC (HGNC:25123)
Function Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).
Cellular Location Secreted. Golgi apparatus {ECO:0000250|UniProtKB:Q5RJI4}
Tissue Location Highly expressed in platelets.
Research Areas
Citations (0)

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Background

Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).

References

Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Manning G.,et al.Science 298:1912-1934(2002).
Bordoli M.R.,et al.Cell 158:1033-1044(2014).

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$ 395.00
Cat# ALS13804
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