PKDCC / SGK493 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q504Y2 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 54kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 91461 |
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Other Names | Extracellular tyrosine-protein kinase PKDCC, 2.7.10.2, Protein kinase domain-containing protein, cytoplasmic {ECO:0000312|HGNC:HGNC:25123}, Protein kinase-like protein SgK493, Sugen kinase 493, Vertebrate lonesome kinase, PKDCC (HGNC:25123) |
Target/Specificity | Human PKDCC |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | PKDCC / SGK493 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PKDCC (HGNC:25123) |
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Function | Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity). |
Cellular Location | Secreted. Golgi apparatus {ECO:0000250|UniProtKB:Q5RJI4} |
Tissue Location | Highly expressed in platelets. |
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Background
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).
References
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Manning G.,et al.Science 298:1912-1934(2002).
Bordoli M.R.,et al.Cell 158:1033-1044(2014).
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