|Application ||WB, IHC-P, E|
|Dilution||IHC-P (10 µg/ml), WB (1:500-1:1000),|
|Other Names||Fanconi anemia group J protein, Protein FACJ, 188.8.131.52, ATP-dependent RNA helicase BRIP1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein C-terminal helicase 1, BRCA1-interacting protein 1, BRIP1, BACH1, FANCJ|
|Target/Specificity||Residues 1233-1249 [NFKPSPSKNKGMFPGFK] of the human BACH1 protein|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||BRIP1 / BACH1 Antibody (aa1233-1249) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.|
|Tissue Location||Ubiquitously expressed, with highest levels in testis.|
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Provided below are standard protocols that you may find useful for product applications.
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
Cantor S.B.,et al.Cell 105:149-160(2001).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Yu X.,et al.Science 302:639-642(2003).
Cantor S.B.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:2357-2362(2004).
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