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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EDF1 / MBF1 Antibody (aa2-14)   

EDF1 / MBF1 Antibody (aa2-14)

Goat Polyclonal Antibody

     
  • IHC - EDF1 / MBF1 Antibody (aa2-14) ALS13835
    Anti-EDF1 antibody IHC of human brain, cortex.
  • IHC - EDF1 / MBF1 Antibody (aa2-14) ALS13835
    Anti-EDF1 antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O60869
Reactivity Human, Mouse, Rat, Monkey, Pig, Chicken, Xenopus, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 16kDa
Dilution IHC-P (3.75-7.5 µg/ml)
Additional Information
Gene ID 8721
Other Names Endothelial differentiation-related factor 1, EDF-1, Multiprotein-bridging factor 1, MBF1, EDF1
Target/Specificity Human EDF1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsEDF1 / MBF1 Antibody (aa2-14) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EDF1
Function Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
Cellular Location Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin
Tissue Location Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues
Research Areas
Citations (0)

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Background

Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.

References

Dragoni I.,et al.J. Biol. Chem. 273:31119-31124(1998).
Kabe Y.,et al.J. Biol. Chem. 274:34196-34202(1999).
Kalnine N.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).

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$ 395.00
Cat# ALS13835
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