|Reactivity||Human, Mouse, Rat, Monkey, Pig, Chicken, Xenopus, Bovine, Dog|
|Dilution||IHC-P (3.75-7.5 µg/ml)|
|Other Names||Endothelial differentiation-related factor 1, EDF-1, Multiprotein-bridging factor 1, MBF1, EDF1|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||EDF1 / MBF1 Antibody (aa2-14) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.|
|Cellular Location||Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin|
|Tissue Location||Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues|
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Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
Dragoni I.,et al.J. Biol. Chem. 273:31119-31124(1998).
Kabe Y.,et al.J. Biol. Chem. 274:34196-34202(1999).
Kalnine N.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
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