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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AP3B1 Antibody (aa2-14)   

AP3B1 Antibody (aa2-14)

Goat Polyclonal Antibody

     
  • IHC - AP3B1 Antibody (aa2-14) ALS13837
    Anti-AP3B1 antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O00203
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 121kDa
Dilution IHC-P (3.75-7.5 µg/ml)
Additional Information
Gene ID 8546
Other Names AP-3 complex subunit beta-1, Adaptor protein complex AP-3 subunit beta-1, Adaptor-related protein complex 3 subunit beta-1, Beta-3A-adaptin, Clathrin assembly protein complex 3 beta-1 large chain, AP3B1, ADTB3A
Target/Specificity Human AP3B1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsAP3B1 Antibody (aa2-14) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AP3B1
Synonyms ADTB3A
Function Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Cellular Location Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Background

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

References

Simpson F.,et al.J. Cell Biol. 137:835-845(1997).
Dell'Angelica E.C.,et al.J. Biol. Chem. 272:15078-15084(1997).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Schmutz J.,et al.Nature 431:268-274(2004).
Kisseljov F.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13837
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