|Reactivity||Human, Mouse, Rat, Hamster, Monkey, Pig, Horse, Bovine|
|Dilution||IHC-P (3.75-7.5 µg/ml)|
|Other Names||Netrin-1, Epididymis tissue protein Li 131P, NTN1, NTN1L|
|Target/Specificity||Human NTN1 / Netrin 1.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||NTN1 / Netrin 1 Antibody (aa498-509) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas Expressed in epididymis (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Meyerhardt J.A.,et al.Cell Growth Differ. 10:35-42(1999).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Mazelin L.,et al.Nature 431:80-84(2004).
Liu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:2951-2956(2009).
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