|Reactivity||Human, Mouse, Rat, Hamster, Monkey, Pig, Horse, Bovine|
|Dilution||IHC-P (3.75-7.5 µg/ml)|
|Other Names||Netrin-1, Epididymis tissue protein Li 131P, NTN1, NTN1L|
|Target/Specificity||Human NTN1 / Netrin 1.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||NTN1 / Netrin 1 Antibody (aa498-509) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas Expressed in epididymis (at protein level)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Meyerhardt J.A.,et al.Cell Growth Differ. 10:35-42(1999).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Mazelin L.,et al.Nature 431:80-84(2004).
Liu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:2951-2956(2009).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.