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DCC Antibody (aa1437-1447)

Goat Polyclonal Antibody

     
  • IHC - DCC Antibody (aa1437-1447) ALS13839
    Anti-DCC antibody IHC of human adrenal.
  • IHC - DCC Antibody (aa1437-1447) ALS13839
    Anti-DCC antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P43146
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Monkey, Pig, Horse, Xenopus, Dog
Host Goat
Clonality Polyclonal
Calculated MW 158kDa
Dilution IHC-P (2.5-5 µg/ml)
Additional Information
Gene ID 1630
Other Names Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC, DCC, IGDCC1
Target/Specificity Human DCC.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDCC Antibody (aa1437-1447) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCC
Synonyms IGDCC1
Function Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells
Research Areas
Citations (0)

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Background

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

References

Hedrick L.,et al.Genes Dev. 8:1174-1183(1994).
Nusbaum C.,et al.Nature 437:551-555(2005).
Fearon E.R.,et al.Science 247:49-56(1990).
Nigro J.M.,et al.Cell 64:607-613(1991).
Cho K.R.,et al.Genomics 19:525-531(1994).

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$ 395.00
Cat# ALS13839
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