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HNF1A / HNF1 Antibody (aa617-631)

Goat Polyclonal Antibody

     
  • IHC - HNF1A / HNF1 Antibody (aa617-631) ALS13844
    Anti-HNF1A / TCF1 antibody IHC of human kidney.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P20823
Reactivity Human, Mouse, Rat, Hamster, Pig, Horse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 67kDa
Dilution IHC-P (3.75-7.5 µg/ml)
Additional Information
Gene ID 6927
Other Names Hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, Liver-specific transcription factor LF-B1, LFB1, Transcription factor 1, TCF-1, HNF1A, TCF1
Target/Specificity Human HNF1A / TCF1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsHNF1A / HNF1 Antibody (aa617-631) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNF1A
Synonyms TCF1
Function Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'- GTTAATNATTAAC-3' (PubMed:12453420, PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10966642}
Tissue Location Liver.
Citations (0)
citation

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Background

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'.

References

Bach I.,et al.Genomics 8:155-164(1990).
Bach I.,et al.EMBO J. 12:4229-4242(1993).
Yamagata K.,et al.Nature 384:455-458(1996).
Yang C.-W.,et al.Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
Gonzalez Ruano E.,et al.Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS13844
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