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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Securin / PTTG1 Antibody (aa148-160)   

Securin / PTTG1 Antibody (aa148-160)

Goat Polyclonal Antibody

     
  • IHC - Securin / PTTG1 Antibody (aa148-160) ALS13846
    Anti-PTTG1 / Securin antibody IHC of human testis.
  • IHC - Securin / PTTG1 Antibody (aa148-160) ALS13846
    Anti-PTTG1 / Securin antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O95997
Reactivity Human, Mouse, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 22kDa
Dilution IHC-P (2.5-5 µg/ml)
Additional Information
Gene ID 9232
Other Names Securin, Esp1-associated protein, Pituitary tumor-transforming gene 1 protein, Tumor-transforming protein 1, hPTTG, PTTG1, EAP1, PTTG, TUTR1
Target/Specificity Human PTTG1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSecurin / PTTG1 Antibody (aa148-160) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTTG1
Synonyms EAP1, PTTG, TUTR1
Function Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer
Research Areas
Citations (0)

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Background

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

References

Dominguez A.,et al.Oncogene 17:2187-2193(1998).
Mu Y.,et al.Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
Kakar S.S.,et al.Cytogenet. Cell Genet. 84:211-216(1999).
Kakar S.S.,et al.Gene 240:317-324(1999).
Zhang X.,et al.Mol. Endocrinol. 13:156-166(1999).

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$ 395.00
Cat# ALS13846
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