|Dilution||IHC-P (3.75-7.5 µg/ml)|
|Other Names||Microtubule-associated proteins 1A/1B light chain 3C, Autophagy-related protein LC3 C, Autophagy-related ubiquitin-like modifier LC3 C, MAP1 light chain 3-like protein 3, MAP1A/MAP1B light chain 3 C, MAP1A/MAP1B LC3 C, Microtubule-associated protein 1 light chain 3 gamma, MAP1LC3C|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||MAP1LC3C / LC3C Antibody (aa121-135) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium.|
|Cellular Location||Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome Note=LC3-II binds to the autophagic membranes|
|Tissue Location||Most abundant in placenta, lung and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.
He H.,et al.J. Biol. Chem. 278:29278-29287(2003).
Gregory S.G.,et al.Nature 441:315-321(2006).
Tanida I.,et al.J. Biol. Chem. 279:36268-36276(2004).
Behrends C.,et al.Nature 466:68-76(2010).
Popovic D.,et al.Mol. Cell. Biol. 32:1733-1744(2012).
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