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KCNN4 / KCa3.1 Antibody (aa227-239)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O15554 |
| Reactivity | Human, Rabbit, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 48kDa |
| Dilution | IHC-P (3.75-7.5 µg/ml) |
| Gene ID | 3783 |
|---|---|
| Other Names | Intermediate conductance calcium-activated potassium channel protein 4, SK4, SKCa 4, SKCa4, IKCa1, IK1, KCa3.1, KCa4, Putative Gardos channel, KCNN4, IK1, IKCA1, KCA4, SK4 |
| Target/Specificity | Human KCNN4. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | KCNN4 / KCa3.1 Antibody (aa227-239) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNN4 |
|---|---|
| Synonyms | IK1, IKCA1, KCA4, SK4 |
| Function | Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed in non-excitable tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
References
Joiner W.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11013-11018(1997).
Ishii T.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11651-11656(1997).
Logsdon N.J.,et al.J. Biol. Chem. 272:32723-32726(1997).
Ghanshani S.,et al.Genomics 51:160-161(1998).
Ghanshani S.,et al.J. Biol. Chem. 275:37137-37149(2000).
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