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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   KCNN4 / KCa3.1 Antibody (aa227-239)   

KCNN4 / KCa3.1 Antibody (aa227-239)

Goat Polyclonal Antibody

     
  • IHC - KCNN4 / KCa3.1 Antibody (aa227-239) ALS13863
    Anti-KCNN4 antibody IHC of human adrenal.
  • IHC - KCNN4 / KCa3.1 Antibody (aa227-239) ALS13863
    Anti-KCNN4 antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O15554
Reactivity Human, Rabbit, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 48kDa
Dilution IHC-P (3.75-7.5 µg/ml)
Additional Information
Gene ID 3783
Other Names Intermediate conductance calcium-activated potassium channel protein 4, SK4, SKCa 4, SKCa4, IKCa1, IK1, KCa3.1, KCa4, Putative Gardos channel, KCNN4, IK1, IKCA1, KCA4, SK4
Target/Specificity Human KCNN4.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsKCNN4 / KCa3.1 Antibody (aa227-239) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNN4
Synonyms IK1, IKCA1, KCA4, SK4
Function Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Widely expressed in non-excitable tissues.
Research Areas
Citations (0)

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Background

Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

References

Joiner W.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11013-11018(1997).
Ishii T.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11651-11656(1997).
Logsdon N.J.,et al.J. Biol. Chem. 272:32723-32726(1997).
Ghanshani S.,et al.Genomics 51:160-161(1998).
Ghanshani S.,et al.J. Biol. Chem. 275:37137-37149(2000).

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$ 395.00
Cat# ALS13863
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