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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SH3PXD2A / TKS5 Antibody (aa1033-1046)   

SH3PXD2A / TKS5 Antibody (aa1033-1046)

Goat Polyclonal Antibody

     
  • IHC - SH3PXD2A / TKS5 Antibody (aa1033-1046) ALS13867
    Anti-SH3PXD2A antibody IHC of human liver.
  • IHC - SH3PXD2A / TKS5 Antibody (aa1033-1046) ALS13867
    Anti-SH3PXD2A antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q5TCZ1
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Xenopus, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 125kDa
Dilution IHC-P (3.75-7.5 µg/ml)
Additional Information
Gene ID 9644
Other Names SH3 and PX domain-containing protein 2A, Adapter protein TKS5, Five SH3 domain-containing protein, SH3 multiple domains protein 1, Tyrosine kinase substrate with five SH3 domains, SH3PXD2A, FISH, KIAA0418, SH3MD1, TKS5
Target/Specificity Human SH3PXD2A.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSH3PXD2A / TKS5 Antibody (aa1033-1046) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SH3PXD2A
Synonyms FISH, KIAA0418, SH3MD1, TKS5
Function Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
Cellular Location Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells
Tissue Location Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas
Research Areas
Citations (0)

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Background

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.

References

Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Okazaki N.,et al.Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Abram C.L.,et al.J. Biol. Chem. 278:16844-16851(2003).

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$ 395.00
Cat# ALS13867
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