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MAP1B Antibody (clone 3G5)

Mouse Monoclonal Antibody

     
  • IHC - MAP1B Antibody (clone 3G5) ALS13880
    Anti-MAP1B antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF
Primary Accession P46821
Reactivity Human, Rat, Bovine
Host Mouse
Clonality Monoclonal
Clone Names 3G5
Calculated MW 271kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 4131
Other Names Microtubule-associated protein 1B, MAP-1B, MAP1B heavy chain, MAP1 light chain LC1, MAP1B
Reconstitution & Storage Stable for 24 months when stored at 2-8°C.
PrecautionsMAP1B Antibody (clone 3G5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP1B
Function Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.
Cellular Location Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, synapse. Cell projection, dendritic spine Note=Colocalizes with DAPK1 in the microtubules and cortical actin fibers.
Volume 125 µl
Research Areas
Citations (0)

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Background

Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.

References

Lien L.L.,et al.Genomics 22:273-280(1994).
Dergunova L.V.,et al.Biomol. Eng. 20:91-96(2003).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (OCT-2009) to UniProtKB.

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$ 395.00
Cat# ALS13880
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