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MKI67 / Ki67 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - MKI67 / Ki67 Antibody (Internal) ALS13887
    Anti-MKI67 / Ki-67 antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P46013
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 359kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 4288
Other Names Antigen KI-67, MKI67
Target/Specificity middle of Ki67 protein
Reconstitution & Storage Stable for 24 months when stored at 2-8°C.
PrecautionsMKI67 / Ki67 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MKI67 (HGNC:7107)
Function Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
Cellular Location Chromosome. Nucleus. Nucleus, nucleolus Note=Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106)
Research Areas
Citations (0)

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Background

Thought to be required for maintaining cell proliferation.

References

Schlueter C.,et al.J. Cell Biol. 123:513-522(1993).
Deloukas P.,et al.Nature 429:375-381(2004).
Gerdes J.,et al.Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
Sueishi M.,et al.J. Biol. Chem. 275:28888-28892(2000).
Takagi M.,et al.J. Biol. Chem. 276:25386-25391(2001).

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$ 395.00
Cat# ALS13887
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