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>   home   >   Products   >   Primary Antibodies   >   LIN41 / TRIM71 Antibody (Internal)   

LIN41 / TRIM71 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - LIN41 / TRIM71 Antibody (Internal) ALS13922
    TRIM71 antibody (0.5 ug/ml) staining of HEK293 lysate (35 ug protein/ml in RIPA buffer).
  • IHC - LIN41 / TRIM71 Antibody (Internal) ALS13922
    Anti-TRIM71 antibody IHC of human brain cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q2Q1W2
Reactivity Human, Rat, Rabbit, Zebrafish, Monkey, Chicken, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 93kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml), WB (0.5-1 µg/ml)
Additional Information
Gene ID 131405
Other Names E3 ubiquitin-protein ligase TRIM71, 6.3.2.-, Protein lin-41 homolog, Tripartite motif-containing protein 71, TRIM71, LIN41
Target/Specificity Human TRIM71.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsLIN41 / TRIM71 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM71
Synonyms LIN41
Function E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity).
Cellular Location Cytoplasm, P-body.
Tissue Location Specifically expressed in testis.
Citations (0)

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Background

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity).

References

Lerner M.,et al.Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
Lancman J.J.,et al.Dev. Dyn. 234:948-960(2005).
Maller Schulman B.R.,et al.Dev. Dyn. 234:1046-1054(2005).
Lee Y.S.,et al.J. Biol. Chem. 280:16635-16641(2005).
Lin Y.C.,et al.Mol. Biol. Evol. 24:2525-2534(2007).

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$ 395.00
Cat# ALS13922
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