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LIN41 / TRIM71 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - LIN41 / TRIM71 Antibody (Internal) ALS13922
    TRIM71 antibody (0.5 ug/ml) staining of HEK293 lysate (35 ug protein/ml in RIPA buffer).
    detail
  • IHC - LIN41 / TRIM71 Antibody (Internal) ALS13922
    Anti-TRIM71 antibody IHC of human brain cerebellum.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q2Q1W2
Reactivity Human, Rat, Rabbit, Zebrafish, Monkey, Chicken, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 93kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml), WB (0.5-1 µg/ml)
Additional Information
Gene ID 131405
Other Names E3 ubiquitin-protein ligase TRIM71, 6.3.2.-, Protein lin-41 homolog, Tripartite motif-containing protein 71, TRIM71, LIN41
Target/Specificity Human TRIM71.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsLIN41 / TRIM71 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM71 (HGNC:32669)
Synonyms LIN41
Function E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233).
Cellular Location Cytoplasm, P-body
Tissue Location Specifically expressed in testis.
Citations (0)
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Background

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity).

References

Lerner M.,et al.Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
Lancman J.J.,et al.Dev. Dyn. 234:948-960(2005).
Maller Schulman B.R.,et al.Dev. Dyn. 234:1046-1054(2005).
Lee Y.S.,et al.J. Biol. Chem. 280:16635-16641(2005).
Lin Y.C.,et al.Mol. Biol. Evol. 24:2525-2534(2007).

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Discontinued
Cat# ALS13922
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