|Application ||WB, IHC-P, IF, ICC, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ICC (5-10 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml)|
|Other Names||Autophagy-related protein 9B, APG9-like 2, Nitric oxide synthase 3-overlapping antisense gene protein, Protein sONE, ATG9B, APG9L2, NOS3AS|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||ATG9B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity).|
|Cellular Location||Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation- induced redistribution depends on ULK1 and ATG13|
|Tissue Location||Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial|
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Provided below are standard protocols that you may find useful for product applications.
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity).
Robb G.B.,et al.J. Biol. Chem. 279:37982-37996(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Yamada T.,et al.J. Biol. Chem. 280:18283-18290(2005).
Fish J.E.,et al.J. Biol. Chem. 282:15652-15666(2007).
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