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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ATP11A Antibody (N-Terminus)   

ATP11A Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - ATP11A Antibody (N-Terminus) ALS13969
    Immunocytochemistry of ATP11A in K562 cells with ATP11A antibody at 10 ug/ml.
  • IF - ATP11A Antibody (N-Terminus) ALS13969
    Immunofluorescence of ATP11A in K562 cells with ATP11A antibody at 20 ug/ml.
  • WB - ATP11A Antibody (N-Terminus) ALS13969
    Western blot analysis of ATP11A in K562 cell tissue lysate with ATP11A antibody at 1 ug/ml in...
  • IHC - ATP11A Antibody (N-Terminus) ALS13969
    Anti-ATP11A antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession P98196
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 130kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 23250
Other Names Probable phospholipid-transporting ATPase IH, 3.6.3.1, ATPase IS, ATPase class VI type 11A, P4-ATPase flippase complex alpha subunit ATP11A, ATP11A, ATPIH, ATPIS, KIAA1021
Target/Specificity Human ATP11A
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsATP11A Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP11A
Synonyms ATPIH, ATPIS, KIAA1021
Function Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.
Cellular Location Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane
Research Areas
Citations (0)

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Background

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.

References

Dunham A.,et al.Nature 428:522-528(2004).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Ohara O.,et al.Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Zhang B.,et al.Blood 106:1355-1361(2005).
Takatsu H.,et al.J. Biol. Chem. 286:38159-38167(2011).

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$ 395.00
Cat# ALS13969
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