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SH3RF2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - SH3RF2 Antibody (C-Terminus) ALS13982
    Immunofluorescence of SH3RF2 in human brain tissue with SH3RF2 antibody at 20 ug/ml.
    detail
  • WB - SH3RF2 Antibody (C-Terminus) ALS13982
    Western blot analysis of SH3RF2 in 3T3 cell lysate with SH3RF2 antibody at (A) 1 and (B) 2 ug/ml.
    detail
  • IHC - SH3RF2 Antibody (C-Terminus) ALS13982
    Anti-SH3RF2 antibody IHC of human placenta.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8TEC5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 79kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 153769
Other Names Putative E3 ubiquitin-protein ligase SH3RF2, 6.3.2.-, Heart protein phosphatase 1-binding protein, HEPP1, Protein phosphatase 1 regulatory subunit 39, RING finger protein 158, SH3 domain-containing RING finger protein 2, SH3RF2, PPP1R39, RNF158
Target/Specificity Human SH3RF2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsSH3RF2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SH3RF2
Function Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623).
Cellular Location Nucleus.
Tissue Location Heart (at protein level). Up-regulated in colon cancer tissues as compared to normal colon tissues (at protein level) Testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta
Research Areas
Citations (0)
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Background

Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function.

References

Chen C.Y.,et al.Biochem. Biophys. Res. Commun. 391:698-702(2010).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Voss M.,et al.BMC Immunol. 10:53-53(2009).
Hendrickx A.,et al.Chem. Biol. 16:365-371(2009).

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Discontinued
Cat# ALS13982
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