SH3RF2 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
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Primary Accession | Q8TEC5 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 79kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 153769 |
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Other Names | Putative E3 ubiquitin-protein ligase SH3RF2, 6.3.2.-, Heart protein phosphatase 1-binding protein, HEPP1, Protein phosphatase 1 regulatory subunit 39, RING finger protein 158, SH3 domain-containing RING finger protein 2, SH3RF2, PPP1R39, RNF158 |
Target/Specificity | Human SH3RF2 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | SH3RF2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SH3RF2 |
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Function | Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623). |
Cellular Location | Nucleus. |
Tissue Location | Heart (at protein level). Up-regulated in colon cancer tissues as compared to normal colon tissues (at protein level) Testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta |
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Background
Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function.
References
Chen C.Y.,et al.Biochem. Biophys. Res. Commun. 391:698-702(2010).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Voss M.,et al.BMC Immunol. 10:53-53(2009).
Hendrickx A.,et al.Chem. Biol. 16:365-371(2009).
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