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NOD3 / NLRC3 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IF - NOD3 / NLRC3 Antibody (Internal) ALS13985
    Immunofluorescence of NOD3 in Jurkat cells with NOD3 antibody at 20 ug/ml.
    detail
  • WB - NOD3 / NLRC3 Antibody (Internal) ALS13985
    Western blot analysis of NOD3 in 3T3 cell lysate with NOD3 antibody at (A) 1 and (B) 2 ug/ml.
    detail
  • IHC - NOD3 / NLRC3 Antibody (Internal) ALS13985
    Anti-NLRC3 antibody IHC of human small intestine.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q7RTR2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 115kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 197358
Other Names Protein NLRC3, CARD15-like protein, Caterpiller protein 16.2, CLR16.2, Nucleotide-binding oligomerization domain protein 3, NLRC3, NOD3
Target/Specificity Human NLRC3
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsNOD3 / NLRC3 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRC3
Synonyms NOD3
Function Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106).
Cellular Location Cytoplasm
Research Areas
Citations (0)
citation

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Background

May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA.

References

Inohara N.,et al.Nat. Rev. Immunol. 3:371-382(2003).
Conti B.J.,et al.J. Biol. Chem. 280:18375-18385(2005).
Jikuya H.,et al.DNA Res. 10:49-57(2003).
Jikuya H.,et al.Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
Huse K.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS13985
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