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BANP Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IF - BANP Antibody (Internal) ALS13993
    Immunofluorescence of BANP in human kidney tissue with BANP antibody at 20 ug/ml.
  • WB - BANP Antibody (Internal) ALS13993
    Western blot analysis of BANP in mouse kidney tissue lysate with BANP antibody at (A) 1 and (B)...
  • IHC - BANP Antibody (Internal) ALS13993
    Anti-BANP antibody IHC of human brain, cerebellum.
  • IHC - BANP Antibody (Internal) ALS13993
    Anti-BANP antibody IHC of human thymus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8N9N5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 56kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 54971
Other Names Protein BANP, BEN domain-containing protein 1, Btg3-associated nuclear protein, Scaffold/matrix-associated region-1-binding protein, BANP, BEND1, SMAR1
Target/Specificity Human BANP
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsBANP Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BANP
Synonyms BEND1, SMAR1
Function Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).
Cellular Location Nucleus.
Tissue Location Down-regulated in breast cancer cell lines.
Citations (0)

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Background

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Birot A.-M.,et al.Gene 253:189-196(2000).
Rampalli S.,et al.Mol. Cell. Biol. 25:8415-8429(2005).
Olsen J.V.,et al.Sci. Signal. 3:RA3-RA3(2010).

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$ 395.00
Cat# ALS13993
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