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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KPNA2 / Importin Alpha 1 Antibody (N-Terminus)   

KPNA2 / Importin Alpha 1 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - KPNA2 / Importin Alpha 1 Antibody (N-Terminus) ALS13994
    Immunofluorescence of KPNA2 in human heart tissue with KPNA2 antibody at 20 ug/ml.
  • WB - KPNA2 / Importin Alpha 1 Antibody (N-Terminus) ALS13994
    Western blot analysis of KPNA2 in rat heart tissue lysate with KPNA2 antibody at (A) 1 and (B) 2...
  • IHC - KPNA2 / Importin Alpha 1 Antibody (N-Terminus) ALS13994
    Anti-KPNA2 antibody IHC of human breast.
  • IHC - KPNA2 / Importin Alpha 1 Antibody (N-Terminus) ALS13994
    Anti-KPNA2 antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P52292
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 58kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 3838
Other Names Importin subunit alpha-1, Karyopherin subunit alpha-2, RAG cohort protein 1, SRP1-alpha, KPNA2, RCH1, SRP1
Target/Specificity Human KPNA2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsKPNA2 / Importin Alpha 1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KPNA2
Synonyms RCH1, SRP1
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed ubiquitously.
Research Areas
Citations (0)

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Background

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

References

Weis K.,et al.Science 268:1049-1053(1995).
Doerr S.,et al.Hum. Genet. 109:479-486(2001).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (JUL-2007) to UniProtKB.

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$ 395.00
Cat# ALS13994
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