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SLC39A7 / ZIP7 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - SLC39A7 / ZIP7 Antibody (N-Terminus) ALS14009
    Immunofluorescence of ZIP7 in human brain tissue with ZIP7 antibody at 20 ug/ml.
    detail
  • WB - SLC39A7 / ZIP7 Antibody (N-Terminus) ALS14009
    Western blot analysis of ZIP7 in mouse brain tissue lysate with ZIP7 antibody at (A) 0.5 and (B)...
    detail
  • IHC - SLC39A7 / ZIP7 Antibody (N-Terminus) ALS14009
    Anti-SLC39A7 antibody IHC of human breast.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q92504
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 50kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 7922
Other Names Zinc transporter SLC39A7, Histidine-rich membrane protein Ke4, Really interesting new gene 5 protein, Solute carrier family 39 member 7, Zrt-, Irt-like protein 7, ZIP7, SLC39A7, HKE4, RING5
Target/Specificity Human SLC39A7
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsSLC39A7 / ZIP7 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC39A7
Synonyms HKE4 {ECO:0000303|PubMed:14525538}, RING
Function Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:29980658, PubMed:28205653). Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (PubMed:29980658, PubMed:22317921, PubMed:28205653). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (By similarity). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts (PubMed:29980658, PubMed:30237509). Mediates Zn(2+)-induced ferroptosis (PubMed:33608508).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein
Tissue Location Widely expressed.
Research Areas
Citations (0)
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Background

Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).

References

Ando A.,et al.Genomics 35:600-602(1996).
Vergara A.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Taylor K.M.,et al.Biochem. J. 377:131-139(2004).

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$ 467.50
Cat# ALS14009
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