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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   VHL / Von Hippel Lindau Antibody (aa34-83)   

VHL / Von Hippel Lindau Antibody (aa34-83)

Rabbit Polyclonal Antibody

     
  • IHC - VHL / Von Hippel Lindau Antibody (aa34-83) ALS14012
    Anti-VHL antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P40337
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Dilution ELISA (1:40000), IHC-P (5 µg/ml),
Additional Information
Gene ID 7428
Other Names Von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL
Target/Specificity VHL (Ab-68) Antibody detects endogenous levels of total VHL protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsVHL / Von Hippel Lindau Antibody (aa34-83) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VHL
Function Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
Cellular Location Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated Colocalizes with ADRB2 at the cell membrane
Tissue Location Expressed in the adult and fetal brain and kidney
Volume 50 µl
Research Areas
Citations (0)

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Background

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.

References

Latif F.,et al.Science 260:1317-1320(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Wenzel M.,et al.Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS14012
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