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CD48 Antibody (clone 3B8-2C2)

Mouse Monoclonal Antibody

     
  • IHC - CD48 Antibody (clone 3B8-2C2) ALS14029
    Anti-CD48 antibody IHC of human tonsil.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P09326
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3B8-2C2
Calculated MW 28kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 962
Other Names CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, SLAM family member 2, SLAMF2, Signaling lymphocytic activation molecule 2, TCT.1, CD48, CD48, BCM1, BLAST1
Target/Specificity Human CD48
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCD48 Antibody (clone 3B8-2C2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD48
Synonyms BCM1, BLAST1
Function Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:27249817, PubMed:12007789). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291). In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T- lymphocytes and NK-cells (PubMed:9841922, PubMed:27249817).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted
Tissue Location Widely expressed on all hematopoietic cells.
Research Areas
Citations (0)
citation

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Background

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

References

Vaughan H.A.,et al.Immunogenetics 33:113-117(1991).
Korinek V.,et al.Immunogenetics 33:108-112(1991).
Staunton D.E.,et al.EMBO J. 6:3695-3701(1987).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).

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Discontinued
Cat# ALS14029
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