CD48 Antibody (clone 3B8-2C2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P09326 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 3B8-2C2 |
Calculated MW | 28kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 962 |
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Other Names | CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, SLAM family member 2, SLAMF2, Signaling lymphocytic activation molecule 2, TCT.1, CD48, CD48, BCM1, BLAST1 |
Target/Specificity | Human CD48 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | CD48 Antibody (clone 3B8-2C2) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD48 |
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Synonyms | BCM1, BLAST1 |
Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:27249817, PubMed:12007789). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291). In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T- lymphocytes and NK-cells (PubMed:9841922, PubMed:27249817). |
Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted |
Tissue Location | Widely expressed on all hematopoietic cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
References
Vaughan H.A.,et al.Immunogenetics 33:113-117(1991).
Korinek V.,et al.Immunogenetics 33:108-112(1991).
Staunton D.E.,et al.EMBO J. 6:3695-3701(1987).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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