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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AKR1C4 / Chlordecone Reductase Antibody (clone 2C11)   

AKR1C4 / Chlordecone Reductase Antibody (clone 2C11)

Mouse Monoclonal Antibody

     
  • WB - AKR1C4 / Chlordecone Reductase Antibody (clone 2C11) ALS14034
    AKR1C4 monoclonal antibody (M01), clone 2C11 Western blot of AKR1C4 expression in MCF-7.
  • WB - AKR1C4 / Chlordecone Reductase Antibody (clone 2C11) ALS14034
    Western blot of AKR1C4 expression in transfected 293T cell line by AKR1C4 monoclonal antibody...
  • IF - AKR1C4 / Chlordecone Reductase Antibody (clone 2C11) ALS14034
    Immunofluorescence of monoclonal antibody to AKR1C4 on HepG2 cell. [antibody concentration 15 ug/ml]
  • IHC - AKR1C4 / Chlordecone Reductase Antibody (clone 2C11) ALS14034
    Anti-AKR1C4 antibody IHC of human tonsil, squamous epithelium.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P17516
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2C11
Calculated MW 37kDa
Dilution IF (15 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 1109
Other Names Aldo-keto reductase family 1 member C4, 1.1.1.-, 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type I, 1.1.1.357, Chlordecone reductase, CDR, 1.1.1.225, Dihydrodiol dehydrogenase 4, DD-4, DD4, HAKRA, AKR1C4, CHDR
Target/Specificity Human AKR1C4
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsAKR1C4 / Chlordecone Reductase Antibody (clone 2C11) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKR1C4
Synonyms CHDR
Function Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Cellular Location Cytoplasm.
Tissue Location Liver specific.
Research Areas
Citations (0)

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Background

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

References

Qin K.-N.,et al.J. Steroid Biochem. Mol. Biol. 46:673-679(1993).
Khanna M.,et al.J. Biol. Chem. 270:20162-20168(1995).
Khanna M.,et al.J. Steroid Biochem. Mol. Biol. 53:41-46(1995).
Kume T.,et al.Pharmacogenetics 9:763-771(1999).
Nishizawa M.,et al.Genes Cells 5:111-125(2000).

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$ 450.00
Cat# ALS14034
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