|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml), WB (1:500-1:1000),|
|Other Names||Tripeptidyl-peptidase 1, TPP-1, 220.127.116.11, Cell growth-inhibiting gene 1 protein, Lysosomal pepstatin-insensitive protease, LPIC, Tripeptidyl aminopeptidase, Tripeptidyl-peptidase I, TPP-I, TPP1, CLN2|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||TPP1 / CLN2 Antibody (clone 3B1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).|
|Cellular Location||Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).
Sleat D.E.,et al.Science 277:1802-1805(1997).
Liu C.-G.,et al.Genomics 50:206-212(1998).
Junaid M.A.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Kim J.W.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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