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TPP1 / CLN2 Antibody (clone 3B1)

Mouse Monoclonal Antibody

     
  • WB - TPP1 / CLN2 Antibody (clone 3B1) ALS14035
    TPP1 monoclonal antibody (M01), clone 3B1 Western blot of TPP1 expression in A-431.
  • IHC - TPP1 / CLN2 Antibody (clone 3B1) ALS14035
    Anti-TPP1 antibody IHC of human kidney, tubules.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O14773
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3B1
Calculated MW 61kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 1200
Other Names Tripeptidyl-peptidase 1, TPP-1, 3.4.14.9, Cell growth-inhibiting gene 1 protein, Lysosomal pepstatin-insensitive protease, LPIC, Tripeptidyl aminopeptidase, Tripeptidyl-peptidase I, TPP-I, TPP1, CLN2
Target/Specificity Human TPP1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsTPP1 / CLN2 Antibody (clone 3B1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TPP1
Synonyms CLN2
Function Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).
Cellular Location Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Tissue Location Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues
Research Areas
Citations (0)

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Background

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).

References

Sleat D.E.,et al.Science 277:1802-1805(1997).
Liu C.-G.,et al.Genomics 50:206-212(1998).
Junaid M.A.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Kim J.W.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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Discontinued
Cat# ALS14035
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