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HEP / EPHB6 Antibody (clone 5D8)

Mouse Monoclonal Antibody

     
  • WB - HEP / EPHB6 Antibody (clone 5D8) ALS14047
    EPHB6 monoclonal antibody clone 5D8 Western blot of EPHB6 expression in PC-12.
    detail
  • WB - HEP / EPHB6 Antibody (clone 5D8) ALS14047
    EPHB6 monoclonal antibody clone 5D8. Western blot of EPHB6 expression in NIH/3T3.
    detail
  • IHC - HEP / EPHB6 Antibody (clone 5D8) ALS14047
    Anti-EPHB6 antibody IHC of human brain, cortex.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O15197
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 5D8
Calculated MW 111kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 2051
Other Names Ephrin type-B receptor 6, HEP, Tyrosine-protein kinase-defective receptor EPH-6, EPHB6
Target/Specificity Human EPHB6
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHEP / EPHB6 Antibody (clone 5D8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPHB6
Function Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
Research Areas
Citations (0)
citation

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Background

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

References

Matsuoka H.,et al.Biochem. Biophys. Res. Commun. 235:487-492(1997).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Jin M.,et al.Oncol. Rep. 19:1277-1283(2008).

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Discontinued
Cat# ALS14047
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